Published in Scientific Papers. Series A. Agronomy, Vol. LXIX, Issue 1
Written by Ana-Maria TĂBĂRAȘU, Florin NENCIU, Lorena-Diana POPA, Tatiana ONISEI, Manuela RASCOL, Petru Alexandru VLAICU, Nicolae-Valentin VLĂDUȚ
The increasing interest in hemp (Cannabis sativa L.) as a source of high-value bioactive compounds has driven the development of efficient and environmentally responsible extraction technologies. Hemp buds contain substantial levels of polyphenols with antioxidant, anti-inflammatory, and antimicrobial properties, making them valuable for functional food, nutraceutical, and cosmetic applications. Conventional extraction methods often require long processing times, high solvent volumes, and provide limited recovery of thermolabile compounds. This study evaluates a hybrid extraction technique that combines percolation with ultrasound-assisted extraction to improve the yield and functionality of polyphenolic fractions from hemp buds. Key parameters - solvent type, percolation rate, ultrasound intensity, and extraction duration - were systematically varied and optimized using response surface methodology. Extraction performance was assessed through total polyphenol content, total flavonoid content, and antioxidant activity, with chromatographic analyses used to quantify major phenolic constituents. The hybrid system outperformed individual techniques, achieving higher polyphenol yields with shorter extraction times and reduced solvent consumption. The resulting extracts showed strong antioxidant capacity associated with their enriched chemical profiles.
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{simplepopup popup="false" name="Citation72"}TABARASU A.M., NENCIU F., POPA L.D., ONISEI T., RASCOL M., VLAICU P.A., VLADUT N.V. 2026, HYBRID PERCOLATION-ULTRASOUND TECHNOLOGY TO IMPROVE EXTRACTION OF BIOACTIVE SUBSTANCES FROM HEMP BUDS FOR AGRICULTURAL APPLICATIONS. Scientific Papers. Series A. Agronomy, Vol. LXIX, Issue 1, ISSN 2285-5785, 587-592. {/simplepopup}